The Indus basin is considered one of the world’s most water-scarce river basins. Food production in the Indus basin mainly depends on irrigated agriculture;; however, the changing climate poses uncertainty in future water availability. Additionally, socio-economic development and population growth will increase food and water demand in the future. Climate-smart agriculture (CSA) can provide a local mechanism for enhancing sustainable food production. This research aims to understand the relationship between field scale (local) CSA and its potential basin-scale impacts. FField-scale CSA practices for enhancing agricultural water productivity will be evaluated. Furthermore, the potential for CSA upup-scaling to enhance sustainable food production and contribute to the sustainable development goals (SDGs) will be assessed.