Water in the Indus basin is currently already scarce. A combination of climate change and rapid socio-economic development is expected to increase the pressure on water resources even further. Regional food production, meanwhile, depends heavily upon irrigated agriculture. The outlook for both the food- and water security SDGs is therefore problematic. This research project combines a modelling approach with direct stakeholder input and field measurements to provide comprehensive, quantitative insight into future food- and water-security. The insight is used to develop robust adaptation strategies that jointly achieve and maintain both SDGs and minimize trade-offs within the water-food-energy nexus.