Since the beginning of the Industrial Revolution, chemical pollution has been a major threat to freshwater ecosystems. In the face of global climate change (GCC), temperature and CO2 levels will increase. It is expected that the effects of chemicals will change due to these additional stressors. In this research project, interactive effects of chemicals and GCC will be determined at different levels of biological organization of freshwater systems. Finally, this research aims to support future ecological risk assessment by providing advanced modelling tools that enable realistic assessment of combined effects of chemicals and GCC on freshwater ecosystems in the future.