The Knowledge to Practice (Water-K2P) project Uganda aims to support water and sanitation safety planners in using an evidence-based approach for managing health outcomes by improving access to scientific data on the efficacy of sanitation technologies and the occurrence and persistence of pathogens in human excreta and sewage. This will be enhanced by providing open access to knowledge resources generated by the Global Water Pathogen Project (GWPP) (www.globalpathogens.org). The project will build a coalition of local, national and global stakeholders involved in the development of ICT-based tools for estimating loads of waterborne pathogens in water sources and selecting sanitation technologies to support decision-making for safe sanitation. Uganda is the first pilot country for the project with a two-year implementation plan and target outcomes. The last 1-year phase of the project will be replicating the same evidence-based approach for safe sanitation in India.