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Development of innovative PBK models to predict exposure of small mammals to anti-coagulant rodenticides, posing high risks to environmental health (urine and/or faeces).

  • 11 November, 2019
  • Wageningen University, Toxicology
  • prof. dr ir IMCM Rietjens
  • dr ir NW van den Brink

Anticoagulant rodenticides (ARs) are widely used in the world in order to control the damage caused by rodents. However, ARs also cause high potential risks to non-target wildlife. The combination of potential environmental risks with the continued use of ARs requires a specific monitoring system to quantify the exposure of non-target species, assess associated risks and verify the effectiveness of risk-mitigation schemes. Physiologically-based kinetic (PBK) modelling and PBK-based reverse dosimetry are proposed in this study to quantify actual exposure of target species to ARs by measuring the concentration of parent compounds and associated metabolites in non-destructively collected faeces and urine.

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Yiming Liu

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