Human health risk of microplastics has been recognized as a global issue. Although recent assessment conclusions from authorities indicate that current scientific literature does not identify a concern for human health, it is well recognized that there are insufficient data to allow for a robust evaluation of the potential human health risks of microplastics. One of the key knowledge gaps is the human exposure to microplastics. Aim of this project is to develop a human exposure probabilistic modelling framework for microplastics, and to collect input data for scenario analyses and validation. The framework will be flexible so as to enable implementation of updates as key processes are further characterized in the future.