The research aimed to develop strategies and technologies for enabling self-sufficiency in water use in Vietnam’s Industrial Zones (IZ). The strategies include measures on the company and IZ level to minimize the environmental impacts of water consumption and wastewater generation, while the technologies aim to support cascading or recycling – a part of the strategic approaches. The Tan Thuan, Hiep Phuoc, and Long Hau IZs were the research partners providing ‘playgrounds’ and case studies for validating the proposed approaches. To attain the research objective, a series of studies were implemented to understand (i) how to improve industrial water efficiency; (ii) how to implement the use of alternative water resources; (iii) how to design an optimal water reuse network; (iv) which hybrid technologies are feasible for maximizing water upgrading and recycling, and (v) what is a practical, systematic approach to support a sustainable water management strategy at the IZ level in Vietnam.