The presence and fate of micropollutants (MPs) in the aquatic environment has raised increasing concern in recent years due to their potential hazard at low concentration (ng/L-μg/L). The conventional wastewater treatment plants (WWTPs) cannot remove some MPs sufficiently. Constructed wetlands (CWs) are one of the promising alternatives as a post-treatment technique to remove MPs from the effluent of WWTPs. The aim of this study is to optimize the design of CWs to enhance the removal efficiency of MPs, and to evaluate the environmental and economic impacts of CWs after optimizations in future application.