Microplastics are prevalent and emerging contaminant but its ecotoxicological and health effects are relatively uncertain. Aside from causing physical damage, microplastics also act as vectors for contaminants in the environment. To date, the bioavailability of contaminants from microplastics have been studied in whole organisms and gut fluids. While whole organism studies are unable to embody different organisms with biological variability, gut fluid studies can account for this and better represent the complexity of the transfer mechanisms. Therefore, this study aims to provide a better assessment of the microplastic facilitated uptake of contaminants via gut fluid studies and models.