Alternative water sources have become increasingly investigated for non-potable applications, however, choosing the most appropriate reuse scheme is complex. Additionally, the resulting social, economic, and environmental considerations can further complicate the decision-making process. The aim of this research is to evaluate the complexities and opportunities for alternative water use as well as the methods of treatment which can connect sources and end uses. A unique hybrid-modelling framework was developed for the purpose of evaluating technologies and supporting decision makers on making the best decisions considering multiple perspectives. It was noted that the focus of current research is almost exclusively from the perspective of product water feasibility. However, this can limit options for brine disposal or reuse and lead to environmental impacts. Therefore, it is recommended that future research reframe alternative water use to meet brine requirements first and then match the product water with potential cross-sectoral applications.